Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

Autor:	Carlos J. Perez-Torres, Rizia Bardhan, Wenxue Chen, Ryan Huschka, Robia G. Pautler, Naomi J. Halas, Marc Bartels, Emilia Morosan, Amit Joshi, Liang L. Zhao
Rok vydání:	2009
Předmět:	Materials science Bioconjugation Fluorophore Nanotechnology Photothermal therapy Condensed Matter Physics Fluorescence Nanoshell Electronic Optical and Magnetic Materials Biomaterials chemistry.chemical_compound Optical imaging chemistry Antibody targeting Electrochemistry Nanoscopic scale
Zdroj:	Advanced Functional Materials. 19:3901-3909
ISSN:	1616-3028 1616-301X
DOI:	10.1002/adfm.200901235
Popis:	Integrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously—fluorescence optical imaging and magnetic resonance imaging—with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell-based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe 3 O 4 and the fluorophore ICG, which results in a high T 2 relaxivity (390mm ―1 s ―1 ) and 45× fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near-IR illumination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::633e5fe2552ef9147ddf0cc12fc95fe2 https://doi.org/10.1002/adfm.200901235 Zobrazit plný text záznamu Plný text