Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

Autor:	Sergey V. Mikhalovsky, Lyuba Mikhalovska, Karl D. Pavey, S. Elizabeth James, Paul E. Tomlins, Stuart L. James, Frank Paul
Rok vydání:	2003
Předmět:	Scaffold Materials science Soft tissue Acoustic energy General Chemistry Dissipation Crystal medicine.anatomical_structure Scaffold material Materials Chemistry medicine Fibroblast Quartz Biomedical engineering
Zdroj:	Journal of Materials Chemistry. 13:654-656
ISSN:	1364-5501 0959-9428
DOI:	10.1039/b300989k
Popis:	A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::633434a944abdb0214c27af52b8ab109 https://doi.org/10.1039/b300989k Zobrazit plný text záznamu