Comparison of Ca2+ Responses to Stimulation of Glutamate Receptors in the Rat Cerebral Cortex after Hypobaric Hypoxia of Different Severities

Autor: A. V. Belyakov, D. G. Semenov, M. O. Samoilov
Rok vydání: 2010
Předmět:
Zdroj: Neuroscience and Behavioral Physiology. 40:1012-1016
ISSN: 1573-899X
0097-0549
DOI: 10.1007/s11055-010-9361-x
Popis: Hypoxia modifies glutamatergic signaling in the brain, inducing prolonged increases in intracellular Ca2+ levels. Depending on the severity of the applied hypoxia, the level and temporospatial profile of Ca2+ accumulation during reoxygenation triggers fundamentally different Ca2+-dependent reactions leading either to cell death or hypoxic tolerance. With the aim of identifying the specific characteristics of the involvement of different glutamate receptors in these alternative processes, the patterns of Ca2+ responses to stimulation of various subtypes of ionotropic and metabotropic glutamate receptors with their agonists were identified in slices of piriform cortex from rats subjected one day previously to severe (pathogenic) or moderate (adaptogenic) hypobaric hypoxia. Hypoxia of different modalities produced different modifications of the Ca2+ responses of all the receptors tested. The most marked differences were seen for Ca2+ responses to stimulation of group I metabotropic glutamate receptors.
Databáze: OpenAIRE
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