Transfer of lidocaine across the sheep placenta to the fetus

Autor:	L. Stanley James, Abraham M. Rudolph, Michael A. Heymann, Cynthia T. Barrett, Hisayo O. Morishima
Rok vydání:	1975
Předmět:	Fetus Lidocaine business.industry Obstetrics and Gynecology Hemodynamics Oxygenation Blood flow Fetal circulation medicine.anatomical_structure Placenta Anesthesia embryonic structures Fetal lamb Medicine business reproductive and urinary physiology medicine.drug
Zdroj:	American Journal of Obstetrics and Gynecology. 122:581-588
ISSN:	0002-9378
Popis:	Placental transfer of lidocaine administered to pregnant sheep and removal of the drug from the fetal circulation were determined. Responses of the hemodynamic and acid-base state in the mother and fetus were also studied. Lidocaine readily crossed the placenta and appeared in the fetal blood as early as one minute following injection. Disappearance of lidocaine in the asphyxiated fetus tended to be slower than in the normal one. Lidocaine produced a transient fall in the fetal heart rate which was accompanied by a decrease in blood pH and oxygenation. Lidocaine also reduced umbilical blood flow and, in some instances, uterine blood flow. Decrease in umbilical blood flow was more pronounced in the initially asphyxiated fetus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63236e3ab6526f4b2d7e66da7cc89d39 https://doi.org/10.1016/0002-9378(75)90053-8 Zobrazit plný text záznamu