Preparation of Arylmercapturic Acids byS-Arylation ofN,N′-Diacetylcystine

Autor:	Igor Linhart, Jan Krouželka
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Copper complex Reaction mechanism Organic Chemistry Cystine Chemical synthesis Dimethyl ester Amino acid chemistry.chemical_compound chemistry Thiol Organic chemistry Physical and Theoretical Chemistry Cysteine
Zdroj:	European Journal of Organic Chemistry. 2009:6336-6340
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200900982
Popis:	A simple convenient method has been developed for the preparation of N-acetyl-S-arylcysteines based on the Chan–Lam–Evans arylation of N,N′-diacetylcystine dimethyl ester with arylboronic acids and used to synthesize a series of arylmercapturic acids. Unlike copper-mediated N-arylation, the S-arylation of neither cysteine nor cystine derivatives proceeded satisfactorily in the presence of air.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Databáze:	OpenAIRE
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