Effect of new anxiolytic CM-346 on bioelectrical activity of cerebral cortex in MR and MNRA rats
| Autor: | Korol'kova Ta, Sergey B. Seredenin, N. E. Sviderskaya, S. N. Kozhechkin, O. Kh. Koshtoyants, I. V. Viglinskaya, Kozhedub Rg |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test medicine.drug_class business.industry medicine.medical_treatment Intraperitoneal injection General Medicine Emotional stress Electroencephalography Anxiolytic General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Endocrinology Cerebral cortex Internal medicine Anesthesia medicine business Diazepam medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 128:1090-1093 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The effect of 2-[2-(morpholin)ethylthio]-5-ethoxybenzimidazole (CM-346) on the EEG of MR and MNRA rats was compared with that of diazepam. Both CM-346 and diazepam reversed stress-induced changes in bioelectrical activity after intraperitoneal injection of 0.9% NaCl. In MR and MNRA rats both drugs decreased the EEG spectral power in the high-frequency θ-band (7.5–8.2 Hz). In MR rats, CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. The data suggest that CM-346 exerts antistressor and anxiolytic effects in animals with passive reactions to emotional stress. |
| Databáze: | OpenAIRE |
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