Recent updates on thienopyrimidine derivatives as anticancer agents

Autor: Menna Tallah M. Sayed, Rasha A. Hassan, Peter A. Halim, Afaf K. El-Ansary
Rok vydání: 2023
Předmět:
Zdroj: Medicinal Chemistry Research. 32:659-681
ISSN: 1554-8120
1054-2523
DOI: 10.1007/s00044-023-03040-y
Popis: Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different synthetic methods for the preparation of heterocyclic thienopyrimidine derivatives. It also highlights the most recent research on the anticancer effects of thienopyrimidines through the inhibition of various enzymes and pathways, which was published within the last 9 years. Graphical Abstract
Databáze: OpenAIRE
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