Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors

Autor:	D. A. J. Lloyd, Simon M. Gabe, A. A. Zabron
Rok vydání:	2008
Předmět:	medicine.medical_specialty Hepatology business.industry Medical record Gastroenterology Prevalence food and beverages medicine.disease carbohydrates (lipids) Liver disease Parenteral nutrition Cholestasis Internal medicine Epidemiology medicine lipids (amino acids peptides and proteins) Pharmacology (medical) Risk factor Intensive care medicine business Body mass index
Zdroj:	Alimentary Pharmacology & Therapeutics. 27:552-560
ISSN:	1365-2036 0269-2813
Popis:	Summary Background Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease in patients receiving home parenteral nutrition. Aims To investigate prevalence of chronic biochemical cholestasis in home parenteral nutrition patients and examine factors influencing its occurrence. Methods Records of all patients receiving home parenteral nutrition for >6 months treated at a single centre were reviewed and plasma biochemistry recorded. Logistic regression analysis was employed to identify factors associated with prevalence of chronic biochemical cholestasis. Results Records of 113 patients were reviewed. The point prevalence of chronic biochemical cholestasis was 24%, increasing to 28% if patients receiving parenteral fluid and electrolytes only were excluded. In multivariate analysis, presence of colon in continuity was associated with a significantly lower prevalence of chronic biochemical cholestasis, while total parenteral calorie intake was associated with a higher prevalence of chronic biochemical cholestasis. No association was seen between small intestinal lengths or between parenteral lipid intake and chronic biochemical cholestasis in multivariate analysis. Conclusions Chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. High parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6312a362abd95bd4e1d24edb676a60b7 https://doi.org/10.1111/j.1365-2036.2008.03615.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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