Synthesis and biological evaluation of a series of HIV-1 protease inhibitors
| Autor: | Randal A. Byrn, Wellington T. Casscles, Michael M. Wick, Robert E. Babine, Schow Steven R, Nan Zhang, Grace C. Hsu, Bernard Dean Johnson, Michael R. Jirousek, Allan Wissner, Richard C. Hastings, Michael P. Trova, Suresh S. Kerwar |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Protease biology Chemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science medicine.disease_cause Biochemistry Virology Virus In vitro Enzyme HIV-1 protease Enzyme inhibitor Drug Discovery medicine biology.protein Molecular Medicine Molecular Biology Biological evaluation |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1595-1600 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80024-4 |
| Popis: | A series of HIV-1 protease inhibitors was prepared and evaluated against the free enzyme for inhibition properties, and for their anti-viral properties in human T lymphoid cells infected with HIVIIIB. Compounds 12, and 19 are the most potent anti-viral agents prepared in this study and are compared to Ro 31-8959, a compound currently in clinical trials for the treatment of AIDS. |
| Databáze: | OpenAIRE |
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