Preparation of (4S)-4-hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopentenone by combination of enzymatic hydrolysis and chemical transformation

Autor:	Akira Maehara, Hidenori Danda, Takeaki Umemura
Rok vydání:	1991
Předmět:	Cyclopentenone Chemical transformation Chemistry Propynyl Organic Chemistry Biochemistry Chemical reaction chemistry.chemical_compound Hydrolysis Enzymatic hydrolysis Drug Discovery Organic chemistry Moiety Enone
Zdroj:	Tetrahedron Letters. 32:5119-5122
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)93443-9
Popis:	(4S)-4-Hydroxy-3-methyl-2-(2′-propynyl)-2-cyclopentenone ((S)-2), which is an important alcohol moiety of optically active pyrethroid insecticides, was prepared from the corresponding racemic acetate ((±)- 1 ) by the combination of enzymatic hydrolysis and chemical transformation in high chemical and optical yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::62fb94059d769158fd7aff7420dec907 https://doi.org/10.1016/s0040-4039(00)93443-9 Zobrazit plný text záznamu