Immunotherapy response modeling by ex-vivo organ culture for lung cancer
| Autor: | Inbal Daniel-Meshulam, Jair Bar, Oranit Zadok, Goni Hout-Siloni, Iris Barshack, Amir Onn, Elizabeta Bab-Dinitz, Alon Ben Nun, Iris Kamer, Teodor Gottfried, Efrat Ofek |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Tumor microenvironment biology business.industry medicine.medical_treatment Immunology FOXP3 Cancer Immunotherapy medicine.disease 03 medical and health sciences 0302 clinical medicine Immune system Oncology Granzyme Cancer immunotherapy Cancer research medicine biology.protein Immunology and Allergy Lung cancer business 030215 immunology |
| Zdroj: | Cancer Immunology, Immunotherapy. 70:2223-2234 |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | One of the major hurdles for the advancement of cancer immunotherapy is lack of robust, accessible experimental models. We aimed to produce an ex-vivo organ culture (EVOC) model of immunotherapy for non-small cell lung cancer (NSCLC). Freshly resected early stage tumors were collected from the operating room, fragmented to clusters |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink