| Autor: |
Natalie Schroyens, Laura Vercammen, Burcu Özcan, Victoria Aurora Ossorio Salazar, Jonas Zaman, Dimitri De Bundel, Tom Beckers, Laura Luyten |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.02.02.478781 |
| Popis: |
The neurotransmitter dopamine plays an important role in the processing of emotional memories, and prior research suggests that dopaminergic manipulations immediately after fear learning can affect the retention and generalization of acquired fear. The current study focuses specifically on the role of dopamine D2 receptors (D2Rs) in differential fear responding in male Wistar rats. In a series of five experiments, D2R dopaminergic drugs were injected systemically after differential cued fear conditioning. One day later, the differential expression of acquired fear was assessed. All five experiments involved the administration of the D2R agonist quinpirole at different doses or saline (n = 12, 16 or 44 rats/treatment condition). Additionally, one of the studies administered the D2R antagonist raclopride (n = 12 rats/treatment condition). We found no indications for an effect of quinpirole or raclopride on differential fear responding during a later drug-free test. Importantly, the evidence for the absence of an effect of quinpirole (1 mg/kg) on CS+ versus CS-discrimination was substantial according to Bayesian analyses and was observed in a highly powered experiment (N = 88). We did observe acute behavioral effects of both quinpirole and raclopride during a locomotor activity test. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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