Synthesis and biological activity of 4-acyl-5-aryl-3-hydroxy-1-(2-hydroxyethylaminoethyl)-3-pyrrolin-2-ones

Autor:	A. L. Moiseev, N. N. Kasimova, M. A. Sheptukha, O. I. Ivanenko, N. G. Ismailova, E. V. Voronina, B. Ya. Syropyatov, V. L. Gein
Rok vydání:	2007
Předmět:	Pharmacology chemistry.chemical_classification chemistry.chemical_compound chemistry Aryl Drug Discovery Pharmacology toxicology Organic chemistry Biological activity Antibacterial activity Aldehyde
Zdroj:	Pharmaceutical Chemistry Journal. 41:476-479
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-007-0105-3
Popis:	A series of 4-acyl-5-aryl-3-hydroxy-1-(2-hydroxyethylaminoethyl)-3-pyrrolin-2-ones (I) and their hydrochlorides (II) were synthesized via reactions of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and N-hydroxyethylethylenediamine. The antibacterial activity of compounds I and the influence of compounds I and II on blood coagulation were studied. All compounds demonstrate pronounced anticoagulant or hemostatic action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::62eaea8ce3dfeb50f3aab86a5e33f9c1 https://doi.org/10.1007/s11094-007-0105-3 Zobrazit plný text záznamu Plný text ve formátu PDF