Infant size and the association between maternal circulating angiogenic factors and preeclampsia
| Autor: | Michael C. Honigberg, Ann M. Thomas, Kee-Hak Lim, Samuel Parry, Thomas F. McElrath, Ellen W. Seely |
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| Rok vydání: | 2018 |
| Předmět: |
Placental growth factor
Pregnancy medicine.medical_specialty 030219 obstetrics & reproductive medicine Obstetrics business.industry Birth weight Obstetrics and Gynecology Gestational age medicine.disease Preeclampsia 03 medical and health sciences 0302 clinical medicine embryonic structures Pediatrics Perinatology and Child Health medicine Gestation Small for gestational age 030212 general & internal medicine Young adult business reproductive and urinary physiology |
| Zdroj: | Journal of Perinatology. 38:456-461 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-018-0074-2 |
| Popis: | To assess the effect of infant size as a marker of placental function on the association between preeclampsia and the ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF). The angiogenic factors sFlt-1 and PlGF were measured prospectively at 26 weeks gestation in 2322 women. Pregnancies were stratified by whether or not they were complicated by preeclampsia, the timing of delivery, and birthweight Z-score. Independent of preeclampsia status, women with small infants (Z 1.0) have a decreased ratio. Among pregnancies yielding small infants, the sFlt-1/PlGF ratio is markedly elevated in preeclamptic pregnancies requiring delivery before 37 weeks (110.0 vs. 17.9, p |
| Databáze: | OpenAIRE |
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