The prognostic significance of stable PSA intervals at varying follow-up times after definitive radiation therapy
| Autor: | Timothy S. Boyd, Mark A. Ritter, Robert C. Orth |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Radiation business.industry Definitive Therapy medicine.medical_treatment urologic and male genital diseases medicine.disease Tumor control Definitive Radiation Therapy Radiation therapy medicine.anatomical_structure Prostate Internal medicine Carcinoma Medicine Radiology Nuclear Medicine and imaging Clinical significance business After treatment |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 42:298 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(98)80448-3 |
| Popis: | Purpose/Objective: The purpose of this study was to determine the prognostic significance of stable 1-year PSA intervals at varying follow-up times after completion of radiation therapy. While pre-treatment PSA has been clearly established as a prognosticator in carcinoma of the prostate, and there is evidence as well suggesting the significance of reaching certain post-treatment PSA nadirs, the need remains, both from a patient advisory and study standpoint, for better early post-therapy predictors of ultimate tumor control. Intervals of stable PSA and when these occur following completion of treatment is one such potential predictor. This study, therefore, sought to determine the clinical significance of stable 1-year PSA intervals occurring at varying times after completion of definitive therapy. Assuming that a stable PSA occurring many years after treatment equates with cure, the study focused upon the extent to which the probability of long-term cure decreased as the time between treatment and the observed stable interval decreased. |
| Databáze: | OpenAIRE |
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