| Autor: |
Franz Kohl, R. Fasching, O. Tilado, Franz Keplinger, E. Aschauer, Gerald Urban, Gerhard Jobst |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Biosensors and Bioelectronics. 7:733-739 |
| ISSN: |
0956-5663 |
| Popis: |
An electrochemical glucose sensor has been integrated, together with a pH sensor, on a flexible polyimide substrate for in vivo applications. The glucose sensor is based on the measurement of H2O2 produced by the membrane-entrapped enzyme glucose oxidase (GOD). To minimize electrochemical interference, an electrode configuration was designed to perform differential measurements. The solid-state pH sensor employs a PVC-based neutral carrier membrane. The enzymes GOD and catalase were immobilized into two layers of photolithographically patterned hydrogels. The intended use of this device is the short-term monitoring of glucose and pH in intensive care units and operating theatres, especially for neurosurgical applications. The developed immobilization technique can also be used to create integrated multi-sensor chips for clinical analysers. The glucose and pH sensor exhibited excellent performance during tests in buffer solutions, serum and whole blood. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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