Isoniazid therapy for Mycobacterium tuberculosis infection in HIV clinics, Los Angeles, California
| Autor: | P. R. Kerndt, A. H. Chang, O. O. Yang, R. Bolan, S. S. Shin, J. K. C. Ghosh, M. P. Dubé |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty education.field_of_study Tuberculosis biology business.industry Cross-sectional study Isoniazid Population Psychological intervention Retrospective cohort study medicine.disease biology.organism_classification Mycobacterium tuberculosis 03 medical and health sciences 030104 developmental biology Infectious Diseases Internal medicine Coinfection Medicine business education medicine.drug |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 20:961-966 |
| ISSN: | 1815-7920 1027-3719 |
| DOI: | 10.5588/ijtld.15.0988 |
| Popis: | SETTING Publicly funded human immunodeficiency virus (HIV) clinics in Los Angeles County, California, USA. BACKGROUND HIV-infected persons are a high priority group for targeted testing and treatment for Mycobacterium tuberculosis infection in the United States. OBJECTIVE To describe rates of isoniazid (INH) initiation and completion among HIV-1 and M. tuberculosis co-infected persons in Los Angeles County. DESIGN We conducted a cross-sectional study using routinely collected surveillance data from publicly funded HIV clinics. We examined differences in INH treatment initiation and completion between four clinic categories: the three largest clinics (Clinics A, B, and C) and 'Other' clinics (pooled data for the remaining 10 clinics). RESULTS During 2010-2013, 802 (5.3%) of 15 029 HIV-1-infected persons tested positive for M. tuberculosis infection. INH was initiated in 581 (72.4%) persons, of whom 457 (78.7%) completed treatment. We found significant differences between clinics in terms of treatment initiation (range 59.1-93.4%) and completion (range 58.8-82.3%). Overall, 57% (457/802) of HIV and M. tuberculosis co-infected persons completed the recommended treatment (range across clinics 34.8-76.3%). CONCLUSION We identified significant gaps in the treatment for M. tuberculosis infection among HIV-infected persons in Los Angeles County. Interventions are needed to improve initiation and completion of treatment for M. tuberculosis infection in this population. |
| Databáze: | OpenAIRE |
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