Absence of Detectable Toxicity in Rats Fed Partially Hydrolyzed Guar Gum (K-13) for 13 Weeks
| Autor: | Yuji Kubo, Toshihiro Maeda, Hidetoshi Oishi, Keiji Sekiya, Takatoshi Koujitani, Masashi Yasuba, Koichi Nishimura, Nobuo Matsuoka |
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| Rok vydání: | 1997 |
| Předmět: |
Guar gum
biology Ratón business.industry 030206 dentistry Pharmacology Toxicology biology.organism_classification 030226 pharmacology & pharmacy Acute toxicity Subchronic toxicity 03 medical and health sciences Hydrolysis 0302 clinical medicine Biochemistry Oral administration Toxicity Medicine business Bacteria |
| Zdroj: | International Journal of Toxicology. 16:611-623 |
| ISSN: | 1092-874X 1091-5818 |
| DOI: | 10.1080/109158197226928 |
| Popis: | Toxicity studies were conducted to evaluate acute and subchronic oral toxicity and mutagenicity of partially hydrolyzed guar gum (K-13). In an acute toxicity study, mice and rats were treated with K-13 at a dose of 6000 mg/ kg. There were no deaths, so the LD50s were >6000 mg/ kg in both species. In a subchronic toxicity study, K-13 was given to rats as a dietary admixture at concentrations of 0.2. 1.0 and 5.0% for 13 weeks. There were no effects attributable to K-13 in any examinations. K-13 proved to have no mutagenic potential in a reverse mutation test using bacteria. |
| Databáze: | OpenAIRE |
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