Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection
| Autor: | A. E. Miroshnikov, Khokhlov Al, V. N. Shabrov, Miroslav Ryska, V. Kubeš, Yu. A. Dzhurko, A. M. Shitova, I. I. Yaichkov, L. N. Shitov |
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| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Bioanalysis Chromatography Human blood Tandem Chemistry 010401 analytical chemistry Mycophenolate Sodium 01 natural sciences High-performance liquid chromatography Mycophenolic acid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Pharmacokinetics Drug Discovery medicine Sample preparation medicine.drug |
| Zdroj: | Pharmaceutical Chemistry Journal. 51:504-507 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was validated according to the Guideline for Validation of Bioanalytical Methods of EMEA and Guidelines for Examination of Drugs. This method was used to study the pharmacokinetics of mycophenolate sodium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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