Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children
| Autor: | Satoshi Takada, Yasuko Takagi, Mio Nishimura, Takeshi Kato, Masami Mizobuchi, Hiroaki Nagase, Masashi Nagai, Hisayuki Matsumoto, Tomoko Horinouchi, Sachiyo Fukushima, Noriyuki Nishimura, Kazumichi Fujioka, Yuka Okada, Jun Saegusa, Kazumi Tomioka, Mieko Yoshioka, Yoko Kawasaki, Yuji Nakamachi, Kandai Nozu, Kazumoto Iijima, Kaori Maeyama |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
05 social sciences Jaundice medicine.disease digestive system Umbilical cord Gastroenterology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Autism spectrum disorder Internal medicine mental disorders Genotype Developmental and Educational Psychology medicine Autism 0501 psychology and cognitive sciences medicine.symptom Allele Risk factor Psychology Allele frequency 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | Journal of Autism and Developmental Disorders. 52:483-489 |
| ISSN: | 1573-3432 0162-3257 |
| Popis: | Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. |
| Databáze: | OpenAIRE |
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