Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections

Autor:	Dieter Staab, Markus Stoeckli, Alain Schweitzer
Rok vydání:	2007
Předmět:	MALDI imaging Chromatography Chemistry Metabolite Condensed Matter Physics Mass spectrometry Mass spectrometric chemistry.chemical_compound Tissue sections Desorption Physical and Theoretical Chemistry Whole body Instrumentation Spectroscopy
Zdroj:	International Journal of Mass Spectrometry. 260:195-202
ISSN:	1387-3806
DOI:	10.1016/j.ijms.2006.10.007
Popis:	The determination of the compound distribution in laboratory animal tissue in early development is a standard process in pharmaceutical research. While this information is traditionally obtained by means of whole-body autoradiography using radiolabeled compounds, this technology does not distinguish between metabolites and parent compound. The technique described in this article, termed matrix-assisted laser desorption/ionization (MALDI) mass spectrometric imaging, can fill this gap by simultaneously measuring compound and multiple metabolites distributed in whole-body tissue sections, using non-labeled compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::62aeeb799b9079e56ec29164ea9e3778 https://doi.org/10.1016/j.ijms.2006.10.007 Zobrazit plný text záznamu Full Text from ScienceDirect