Protein–protein interactions of ASPP2: an emerging therapeutic target

Autor:	Assaf Friedler, Anat Iosub-Amir
Rok vydání:	2014
Předmět:	Pharmacology Senescence Organic Chemistry Cellular pathways Pharmaceutical Science Biology Biochemistry Protein–protein interaction Cell biology Drug development Apoptosis Drug Discovery Cell polarity Cancer cell Molecular Medicine
Zdroj:	Med. Chem. Commun.. 5:1435-1443
ISSN:	2040-2511 2040-2503
DOI:	10.1039/c4md00147h
Popis:	The pro-apoptotic ASPP2 protein plays a central role in regulating apoptosis in both p53-dependent and p53-independent pathways. It has become clear in recent years that ASPP2 plays also a role in other important cellular processes like senescence and regulating cell polarity. ASPP2 interacts with numerous proteins in order to exert its pro-apoptotic effect while some other proteins inhibit its pro-apoptotic activity. These interactions are emerging potential targets for activation or inhibition. Drugs that activate ASPP2 may not only induce apoptosis of cancer cells, but also affect other disease-related cellular pathways. Here we review the interactions of ASPP2 with its partner proteins and their potential targeting for drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::629fafe0e6d921cd78cae94653d99643 https://doi.org/10.1039/c4md00147h Zobrazit plný text záznamu