Prognosis Factors of Young Patients Undergoing Curative Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study
| Autor: | Kongying Lin, Yao Huang, Yongyi Zeng, Jianxing Zeng, Pengfei Guo, Jingfeng Liu, Huocheng Liu, Jinhua Zeng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hepatitis B virus medicine.medical_specialty Cirrhosis Proportional hazards model business.industry medicine.medical_treatment medicine.disease medicine.disease_cause Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine medicine Resection margin Liver function Hepatectomy Stage (cooking) business |
| Zdroj: | Cancer Management and Research. 12:6597-6606 |
| ISSN: | 1179-1322 |
| Popis: | Background The prognosis of young and older patients with hepatocellular carcinoma (HCC) is controversial. We aim to compare the clinicopathological features and prognosis of young (age ≤40 years) versus older patients (aged >40 years) with hepatitis B virus (HBV)-related HCC after curative resection. Methods A total of 4504 patients with HBV-related HCC who underwent curative resection were included in this study and divided into young group (n=699) and older group (n=3805). Subgroup analyses were conducted to compare. Independent risk factors were identified by Cox regression analysis. Results Young patients had better ALBI grade, lower rates of liver cirrhosis, higher rates of elevated serum AFP levels, larger tumor size, higher rates of microvascular invasion and macrovascular invasion, higher rates of Edmondson grade III-IV, lower rates of tumor capsular, more advanced AJCC TNM stages and more advanced BCLC stages than older patients (All p |
| Databáze: | OpenAIRE |
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