Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

Autor:	Danilo Vojvodic, Cveta Špadijer-Mirković, Branislav Belić, Aleksandar Perić
Rok vydání:	2016
Předmět:	Eosinophil cationic protein medicine.drug_class business.industry medicine.medical_treatment Inflammation respiratory system Eosinophil 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Otorhinolaryngology Nasal spray Clara cell protein 16 Cytology Immunology medicine Immunology and Allergy Corticosteroid medicine.symptom 030223 otorhinolaryngology business Fluticasone medicine.drug
Zdroj:	International Forum of Allergy & Rhinology. 6:529-536
ISSN:	2042-6976
DOI:	10.1002/alr.21710
Popis:	Background Clara cell protein 16 (CC16) is an anti-inflammatory protein mainly expressed in the epithelial cells in the upper and lower airways. Eosinophil cationic protein (ECP) is an important marker of eosinophil activity in chronic inflammatory sinonasal diseases. The aim of this study was to evaluate mucosal production of CC16 and ECP in patients with perennial allergic rhinitis (PAR), nonallergic and allergic patients with chronic rhinosinusitis with nasal polyposis (CRSwNP), before and after nasal corticosteroid administration. Methods Twenty patients with PAR, 20 nonallergic CRSwNP patients, 20 allergic CRSwNP patients, and 20 healthy controls were included. Mucosal cytology samples were taken from all participants for quantification of eosinophils. CC16 and ECP levels were measured in the nasal secretion samples. The patients with chronic sinonasal inflammation were treated with fluticasone nasal spray for 14 days. Nasal symptoms assessment, cytological examination, and CC16 and ECP nasal fluid measurements were performed before and after the corticosteroid treatment. Results Mean CC16 concentrations in nasal secretions were significantly lower in patients with PAR (p < 0.05) and allergic CRSwNP patients (p < 0.01) compared to controls. Mean ECP levels were significantly higher in patients with PAR, nonallergic CRSwNP patients, and allergic CRSwNP patients compared to the control group (p < 0.001, p < 0.01, p < 0.001, respectively). After nasal corticosteroid therapy, we found a highly significant increase of CC16 (p < 0.001) and reduction of ECP (p < 0.001) in nasal secretions in all 3 groups of patients. Conclusion CC16 and ECP measured in nasal secretions could be reliable markers for assessment of the recovery function of sinonasal mucosa during corticosteroid treatment.
Databáze:	OpenAIRE
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