Towards a Model-Based Experimental Design of the Maturation Process of Biohybrid Heart Valves
| Autor: | Dirk Abel, Jonas Gesenhues, Lorenz Pyta, Kirsten Voß, Thomas Schmitz-Rode, Petra Mela |
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| Rok vydání: | 2019 |
| Předmět: |
0209 industrial biotechnology
State variable Design of experiments 020208 electrical & electronic engineering Experimental data Sobol sequence 02 engineering and technology Variance (accounting) 020901 industrial engineering & automation Control and Systems Engineering 0202 electrical engineering electronic engineering information engineering Maturation process Sensitivity (control systems) Diffusion (business) Biological system Mathematics |
| Zdroj: | IFAC-PapersOnLine. 52:113-120 |
| ISSN: | 2405-8963 |
| DOI: | 10.1016/j.ifacol.2019.12.245 |
| Popis: | Model-based experimental designs minimize the experimental effort while maximizing the amount of analyzable experimental data. In this paper, an initial mathematical model of the spatially distributed maturation process of tissue engineered heart valves is developed for a model-based experimental design. The model contains the state variables cell amount, collagen concentration and elastin concentration. Based on the developed model, a variance-based sensitivity analysis using Sobol’s method is performed. The results indicate that all model parameters influence the model solution, while the variance of the parameters related to cell diffusion comprises an exceeding influence. Consequently, corresponding experiments should especially focus on those parameters. |
| Databáze: | OpenAIRE |
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