Comparative effects of artemether and in combination with diminazene aceturate in the treatment of experimental Trypanosoma brucei brucei infection in Wistar rats

Autor:	Mohammed Mamman, Dahiru Sani, Kelvin Olutimilehin Jolayemi, Ochuko Orakpoghenor, Magdalene Ogbonneya Okoronkwo, Collins Chimezie Udechukwu
Rok vydání:	2021
Předmět:	medicine.medical_specialty Hematology biology business.industry Physiology Trypanosoma brucei biology.organism_classification Internal medicine parasitic diseases Medicine Diminazene aceturate Parasitology Artemether medicine.symptom business Weight gain medicine.drug
Zdroj:	Journal of Parasitic Diseases. 45:673-682
ISSN:	0975-0703 0971-7196
Popis:	This study assessed the effects of artemether and in combination with diminazene aceturate on parasitaemia, weight, haematology and pathology induced by experimentally Trypanosoma brucei brucei infection in Wistar rats. Fifty adult rats comprising 25 each of males and females were assigned into 5 groups of ten rats (five males and five females). Rats in group I was uninfected while groups II-V were infected with T b brucei. Groups II were untreated; III administered diminazene aceturate once; IV and V administered artemether only and in combination with diminazene aceturate respectively for 5 days. Parasitaemia was determined daily, blood was collected for haematology and weight obtained every four days for a period of 32 days. At 24 days post-treatment, rats were humanely euthanized and organs harvested for pathological examination. Results revealed parasitaemia at day 4 post-infection, significant (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::62903d4e6be89a84b9206973aae6940f https://doi.org/10.1007/s12639-021-01350-9 Zobrazit plný text záznamu Full text from SpringerLink