Synthesis of Novel 6-(3,5-Dimethyl-1H-Pyrazol-1-yl)Pyridazin-3(2H)-One Derivatives and their Preliminary Biological Evaluation

Autor:	Tiruhi A. Gomktsyan, Roza S. Shainova, A. P. Yengoyan, Armen V. Karapetyan
Rok vydání:	2018
Předmět:	010404 medicinal & biomolecular chemistry 010405 organic chemistry Chemistry Simple (abstract algebra) General Chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Biological evaluation
Zdroj:	Journal of Chemical Research. 42:535-539
ISSN:	2047-6507 1747-5198
Popis:	Simple and accessible pathways for the synthesis of a series of novel 6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3(2H)-one derivatives including compounds with a combination of a pyrazolyl-pyridazine moiety with pyrimidine, 1,3,5-triazine and 1,3,4-oxadiazole rings in the same molecules were established. The tautomeric structures of 3-oxopyridazine and 5-thioxo-1,3,4-oxadiazole rings and also the position of their alkylation were shown. At preliminary screening the synthesised compounds showed pronounced plant growth stimulant activity. The most active compounds were selected for deeper studies and further field trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::628cae2c1e98d1f16d1d1ef8ef0ee089 https://doi.org/10.3184/174751918x15389922302823 Zobrazit plný text záznamu Plný text ve formátu PDF