Pharmacokinetic study of medicinal polymers: Models based on dextrans

Autor:	V. V. Sedov, A. E. Vasil'ev, Pimenova Gn, V. A. Matveev, Kulakov Vn
Rok vydání:	1985
Předmět:	Pharmacology chemistry.chemical_classification Chromatography Kinetics Polysaccharide Chemical kinetics chemistry.chemical_compound Residue (chemistry) Dextran Pharmacokinetics chemistry Drug Discovery Fluorescein Fluorescein isothiocyanate
Zdroj:	Pharmaceutical Chemistry Journal. 19:240-244
ISSN:	1573-9031 0091-150X
DOI:	10.1007/bf00833350
Popis:	The authors study the pharmacokinetics of dextrans with various molecular masses modified by fluorescein isothiocyanate (FITC) using a radioisotope method. The radionuclide /sup 125/I was selectively bound to a FITC residue attached to the polysaccharide by electrochemical iodination under potentiostatic conditions. In the experiments, dextrans modified by FITC were labeled with /sup 125/I (DF-/sup 125/I) by electrochemical iodination. The separation of DF-/sup 125/I and FITC from ionic forms of the radionuclide not bound to the polymer was carried out. The properties of the samples obtained are presented. The radioactivity accumulated in the rate organs and urine studied are shown. The features of DF-/sup 125/I behavior in the blood and liver are examined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6289ea728e7cb52bfb2176bcbde69c84 https://doi.org/10.1007/bf00833350 Zobrazit plný text záznamu Full text from SpringerLink