Regulation of neutrophil apoptosis by cytokines: Role of IAP family

Autor:	Seiichi Kitagawa, Takayuki Kato, Fumihiko Hato, Erina Sakamoto
Rok vydání:	2005
Předmět:	biology Chemistry Organic Chemistry Chronic neutrophilic leukemia Neutrophil apoptosis Stimulation medicine.disease Inhibitor of apoptosis Biochemistry XIAP Proinflammatory cytokine Cell biology Survivin medicine biology.protein STAT3
Zdroj:	Ensho Saisei. 25:525-531
ISSN:	1880-5795 1346-8022
Popis:	Human neutrophils undergo spontaneous apoptosis, and spontaneous neutrophil apoptosis is delayed in the presence of various inflammatory cytokines, including G-CSF, GM-CSF, IFN-α and IFN-γ. These cytokines exert the antiapoptotic effect on human neutrophils in a protein-synthesis dependent mechanism, indicating that certain antiapoptotic molecules are up-regulated by stimulation with these cytokines. Human neutrophils express Bcl-2 family (Mcl-1, A1 and Bcl-XL) and IAP (inhibitor of apoptosis) family (cIAP1, cIAP2, XIAP and survivin) members, both of which may be involved in cytokine-mediated anti-apoptotic effect. Among these molecules, cIAP2 is found to be selectively up-regulated by stimulation with G-CSF, IFN-α and IFN-γ via activation of the JAK2/STAT3 pathway, and overexpression of cIAP2 is detected in a patient with chronic neutrophilic leukemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6285832e11f2d6dc6bc08602edf33721 https://doi.org/10.2492/jsir.25.525 Zobrazit plný text záznamu