Performance of ovarian cyst fluid fine-needle aspiration cytology
| Autor: | Kimberly Levinson, Dorothy L. Rosenthal, Christopher J. VandenBussche, Amy G. Zhou |
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| Rok vydání: | 2017 |
| Předmět: |
Cancer Research
medicine.medical_specialty 030219 obstetrics & reproductive medicine Ovarian cyst business.industry Cancer Gold standard (test) Malignancy medicine.disease Pre- and post-test probability Surgical pathology 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Ovarian carcinoma Cytology Medicine Radiology business |
| Zdroj: | Cancer Cytopathology. 126:112-121 |
| ISSN: | 1934-662X |
| DOI: | 10.1002/cncy.21911 |
| Popis: | BACKGROUND Although ovarian fine-needle aspiration (FNA) cytology is not commonly used as a primary modality of diagnosis for patients with ovarian lesions, many ovarian cysts are aspirated intraoperatively and occasionally for diagnostic purposes. Therefore, the ability to interpret these specimens remains critical. Previous studies have suggested a high specificity but low sensitivity as a limitation. The objective of the current study was to further explore the use and performance of ovarian cyst FNA for diagnosing malignancy at the study institution. METHODS The electronic database was searched from 1998 through 2016 for ovarian cyst fluid cytology specimens; any concurrent or follow-up surgical pathology; and clinical information including patient age, radiology findings, and procedure type. Test performance was calculated using the surgical pathology diagnosis as the gold standard. RESULTS A total of 459 ovarian cyst FNA specimens had the following diagnoses: 416 (90.6%) were diagnosed as benign, 32 (7.0%) as atypical, 4 (0.9%) as suspicious, and 7 (1.5%) as malignant. Overall, 300 specimens (65.4%) had a corresponding surgical pathology specimen. On follow-up, the rate of malignancy (including borderline neoplasms) for benign FNA was 10 of 264 specimens (3.8%), that for atypical FNA was 0 of 24 specimens (0%), that for suspicious FNA was 5 of 5 specimens (100%), and that for malignant FNA was 7 of 7 specimens (100%). Test sensitivity was 54.0% and test specificity was 100%. The positive predictive value was 1.00 and the negative predictive value was 0.97, with a disease (malignancy) prevalence of 7.33%. CONCLUSIONS Ovarian cyst fluid cytology is highly specific and moderately sensitive for the detection of ovarian malignancies. A negative FNA is reassuring for patients with a low pretest probability of malignancy. Cancer (Cancer Cytopathol) 2017. © 2017 American Cancer Society. |
| Databáze: | OpenAIRE |
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