| Autor: |
Sung Hee Kim, Myung-Joo Kang, Seung-Wook Ham, Jaehwi Lee, Young-Mi Park, Young Wook Choi, Tae-Jong Im, Bo-Gyun Kim, Il-Young Oh |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Bulletin of the Korean Chemical Society. 28:1535-1538 |
| ISSN: |
0253-2964 |
| DOI: |
10.5012/bkcs.2007.28.9.1535 |
| Popis: |
The work presented in this paper represents a study of the rate and extent of transdermal penetration of three synthetic hexapeptides consisting only of glycine (Gly) and phenylalanine (Phe) as the constituent amino acids and they include Phe-Gly-Gly-Gly-Gly-Gly (Pep-1), Phe-Phe-Gly-Gly-Gly-Gly (Pep-2), and Phe-Phe-PheGly-Gly-Gly (Pep-3). The present study demonstrated the extent to which the peptides having a high metabolic stability were transdermally transported from the various vehicles. The results of this study appear to indicate that minor differences in the lipophilicity of the synthetic hexapeptides have a slight influence on the rate and extent of transport. In the presence of terpene permeation enhancers, together with ethanol (i.e., menthone/ EtOH, carveol/EtOH or cineole/EtOH), the peptides were more rapidly penetrated through the skin and among the terpenes tested, cineole was the most effective for all three peptides. The maximum enhancement ratio of approximately 2 was achieved by cineole in 50% ethanol solution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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