Determination and correlation of solubility with thermodynamic analysis of lidocaine hydrochloride in pure and binary solvents
| Autor: | Jiejie Dong, Baohua Wang, Zhirong Wang, Guangyi Zhou, Qunsheng Li, Zhili Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Methyl acetate
Enthalpy Thermodynamics 02 engineering and technology Lidocaine Hydrochloride 010402 general chemistry Condensed Matter Physics 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Gibbs free energy Solvent symbols.namesake chemistry.chemical_compound 020401 chemical engineering chemistry Materials Chemistry symbols Non-random two-liquid model 0204 chemical engineering Physical and Theoretical Chemistry Solubility Dissolution Spectroscopy |
| Zdroj: | Journal of Molecular Liquids. 265:442-449 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2018.06.035 |
| Popis: | The objective of this work was to measure and correlate the solubility of lidocaine hydrochloride in eight pure solvents, including ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, methyl acetate, water, and binary mixtures at (291.15 to 331.15) K by using gravimetric method under atmospheric pressure. The results reveal that the solubility of lidocaine hydrochloride increases with increasing temperature in all solvent selected. The modified Apelblat equation, van’t Hoff equation, λh equation, Wilson model and NRTL model were successfully used to correlate the experimental solubility in pure solvents and binary solvent mixtures. In addition, the thermodynamic properties of dissolution of Lidocaine hydrochloride such as Gibbs energy (∆G°sol), molar enthalpy of dissolution (∆H°sol), and molar entropy of dissolution (∆S°sol ) were calculated. Consequently, the experimental solubility and correlation equations can be used as essential data and simulation models in the purification and separation of lidocaine hydrochloride. |
| Databáze: | OpenAIRE |
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