Unexplained Late-Onset Hemolytic Jaundice Preceded by High Fetal Hemoglobin Level in an Extremely Low Birth Weight Infant
| Autor: | Aya Okahashi, Ichiro Morioka, GoEun Kwon, Erina Nakahara, Kazumasa Fuwa, Nobuhiko Nagano, Chihiro Nozaki, Hiroshi Yagasaki, Hitoshi Kanno |
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| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities business.industry Physiology Late onset Jaundice General Biochemistry Genetics and Molecular Biology Methemoglobin chemistry.chemical_compound Red blood cell medicine.anatomical_structure chemistry hemic and lymphatic diseases Carboxyhemoglobin Fetal hemoglobin medicine Etiology Hemoglobin medicine.symptom business |
| Zdroj: | Clinical Laboratory. 66 |
| ISSN: | 1433-6510 |
| Popis: | Background Preterm infants sometimes have transient late-onset hemolytic jaundice; however, the etiology has yet to be determined. Case presentation In our case, fetal hemoglobin (HbF) level increased significantly to 100% at 23 days of age. Levels of methemoglobin and carboxyhemoglobin also increased to 2.9% and 3.5%, respectively, following the elevated HbF level. At 26 days, hemolytic jaundice developed. No abnormality of red blood cell membranes and enzyme activities was found. Conclusions The etiology of late-onset hemolytic jaundice in preterm infants may associate with an impaired switching from HbF to adult hemoglobin (HbA) or reverse switching from HbA to HbF. |
| Databáze: | OpenAIRE |
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