Anti-Phospholipid Antibodies against Phosphatidylinositol, and Phosphatidylserine are More Significant in Reproductive Failure than Antibodies against Cardiolipin only
| Autor: | V Krauz, Renata Sucha, Zdenka Ulcova-Gallova, Katerina Bibkova, Pavla Nováková, Miroslav Balvin, Lucie Milichovska, Zdenek Rokyta, Jir̆i Turek, Z Micanová |
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| Rok vydání: | 2005 |
| Předmět: |
In vitro fertilisation
medicine.medical_treatment Immunology Obstetrics and Gynecology Phosphatidylserine Biology medicine.disease Reproductive failure Miscarriage Andrology chemistry.chemical_compound Immune system Reproductive Medicine chemistry Cardiolipin medicine biology.protein Immunology and Allergy Phosphatidylinositol Antibody |
| Zdroj: | American Journal of Reproductive Immunology. 54:112-117 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2005.00294.x |
| Popis: | Problem The humoral immune response to phospholipids was investigated in women with reproductive failure [1073 women after one in vitro fertilization (IVF), 853 women after two and more IVF, 627 women after three and more repeated spontaneous miscarriages or missed abortions, 412 women after diagnostic laparoscopy] and compared with that of 391 healthy fertile women. Method of study Sera from all women in the study were tested by enzyme-linked immunosorbent assay (ELISA) for the detection of IgG, IgA, and IgM isotypes of antibodies against seven phospholipids (aPLs), i.e. cardiolipin, L-phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylacid as well as against β2-glycoprotein I. Results Patients after two and more IVF (48 and 50%, respectively), patients with three and more repeated spontaneous miscarriages (50 and 46.5%, respectively) are associated with significantly higher serum levels of aPLs against inositol, and l-serine (P |
| Databáze: | OpenAIRE |
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