| Autor: |
Jean M. Taylor, J. K. Scott, Frank A. Smith, Harold C. Hodge, Elliott A. Maynard |
| Rok vydání: |
1961 |
| Předmět: |
|
| Zdroj: |
Toxicology and Applied Pharmacology. 3:278-289 |
| ISSN: |
0041-008X |
| DOI: |
10.1016/0041-008x(61)90067-9 |
| Popis: |
1. 1. The 30-day LD 50 of sodium fluoride administered intravenously as a 2% aqueous solution in the young rat (75 days old) was 26 mg/kg. The lethal action of sodium fluoride appeared to involve two mechanisms: one causing death in a few hours and the other in 3–10 days. 2. 2. Renal injury did not appear to be the cause of the delayed deaths. Single doses of sodium fluoride (20 and 30 mg/kg, intravenously) produced a mild necrosis of the tubular epithelium in the inner third of the cortex. The necrosis was evident on the first and third days after treatment. Regeneration began by the fifth day and was nearly complete by the ninth day. The renal lesion was relatively limited. A few rats receiving a single dose of sodium fluoride showed a dilatation of the tubules at the junction of the cortex and medulla. 3. 3. Renal functions were deranged temporarily by near lethal doses. A single dose of sodium fluoride of 20 or 30 mg/kg, intravenously, increased urine volume and decreased specific gravity. Sugar excretion was markedly increased the first day after treatment and then decreased below normal for several days. Protein excretion was slightly increased. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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