Safety and Anti-Fatigue Activity of Ayurvedic Formulation Sramahara Mahaakaasaya - A Pre-Clinical Study

Autor:	Bidhan Mahajon, A. Ramamurthy, Rupashri Nath, Manish K. Gautam, Neeladri Das, Partha Roy
Rok vydání:	2023
Předmět:	Health Toxicology and Mutagenesis Toxicology
Zdroj:	Toxicology International. :493-505
ISSN:	0976-5131 0971-6580
DOI:	10.18311/ti/2022/v29i4/30296
Popis:	An experimental evaluation of anti-fatigue activity of Shramahara Mahaakashaaya (SM) and its applicability in sports medicine has been systematically evaluated. Aqueous, ethanolic and petroleum ether extracts of SM granules (200mg/kg) were studies for light-dark model test for assessment anti-anxiety effect, rota-rod test for assessment of the effect on muscle tone and muscle balance, weight loaded forced swimming test for assessment of anti-fatigue activity. The acute toxicity study of SM granules has also been evaluated as per the OECD 423. SM granules showed significant anti-fatigue activity in different experimental models and found safe up to 2000mg/kg body weight dose. The results provide an important basis for considering Shramahara Mahaakashaaya (SM) as an alternative medicine having anti-fatigue effects which can be further included in the sports medicine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::624402c2f866021aaac5b0586f15d8d1 https://doi.org/10.18311/ti/2022/v29i4/30296 Zobrazit plný text záznamu