In vitro antitumour activity of two ferrocenyl metallodendrimers in a colon cancer cell line
| Autor: | Gregory S. Smith, Eva Fischer-Fodor, Cristina Szabo, Sorin-Aurel Dorneanu, Nadia Baartzes, Florica Imre-Lucaci, Mihai Cenariu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
education.field_of_study Reactive oxygen species 010405 organic chemistry Chemistry Cell growth Cell Population 010402 general chemistry 01 natural sciences In vitro 0104 chemical sciences Inorganic Chemistry medicine.anatomical_structure Cell culture Materials Chemistry Cancer research medicine Cytotoxic T cell Inducer Physical and Theoretical Chemistry education |
| Zdroj: | Inorganic Chemistry Communications. 98:75-79 |
| ISSN: | 1387-7003 |
| Popis: | The antitumour activity of a tetranuclear (1) and trinuclear (2) ferrocenyl-amino complex was evaluated against two colon cancer cell lines, the wild-type HT-29 and mutant DLD-1. The compounds displayed moderate micromolar cytotoxic activity in both cell lines. The DLD-1 tumour cell population proved more susceptible, as compounds 1 and 2 showed greater inhibition of cell growth than in the HT-29 cell line. Compounds 1 and 2 were capable of accumulation inside the tumour cells, the cellular uptake displaying good correlation with the early apoptosis induction. Complex 2 is a better inducer of reactive oxygen species in tumour cells. |
| Databáze: | OpenAIRE |
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