| Autor: |
Marco Gusciglio, Marco Alessandri, Alessandro Giuliani, Chiara Mangano, Mercedes Fernandez, Vito Antonio Baldassarro, Laura Calzà, Luciana Giardino, Roberta Torricella, Sandra Sivilia, Luca Lorenzini |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Current Topics in Medicinal Chemistry. 13:1843-1852 |
| ISSN: |
1568-0266 |
| DOI: |
10.2174/15680266113139990140 |
| Popis: |
The drug discovery for disease-modifying agents in Alzheimer disease (AD) is facing a failure of clinical trials with drugs based on two driving hypotheses, i.e. the cholinergic and amyloidogenic hypotheses. In this article we recapitulate the main aspects of AD pathology, focusing on possible mechanisms for synaptic dysfunction, neurodegeneration and inflammation. We then present the pharmacological and neurobiological profile of a novel compound (CHF5074) showing both anti-inflammatory and gamma-secretase modulatory activities, discussing the possible time-window for effective treatment in an AD transgenic mouse model. Finally, the concept of cognitive reserve is introduced as possible target for preventive therapies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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