Molecular circulating tumor DNA response to identify long-term survival in patients receiving immunotherapy with initial radiologic stable disease
Autor: | Shaad Essa Abdullah, Phillip A. Dennis, Chen Gao, Jamie E. Chaft, Matthew D. Hellmann, Brandon W. Higgs, Qu Zhang, Neil H. Segal |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Journal of Clinical Oncology. 37:2546-2546 |
ISSN: | 1527-7755 0732-183X |
Popis: | 2546 Background: Early on-treatment changes in ctDNA may identify responders to immunotherapy and complement radiologic assessment of benefit. Here we investigate how early changes in ctDNA associate with long-term survival following treatment with immunotherapy, and if differential patterns in molecular ctDNA response (MCR) among patients with radiologic stable disease (SD) at first on-treatment scan could identify patients deriving benefit from treatment. Methods: Paired pre- and on-treatment (week 6-8) plasma samples from 3 cohorts of patients treated with durvalumab (D) +/- tremelimumab (D+T) were evaluated (NCT01693562, NCT02087423, NCT02261220). CtDNA was profiled with the 73-gene Guardant 360 assay. Nonsynonymous variants were summarized per patient to calculate variant allelic frequency changes (dVAF) and on-treatment variant allele frequency (pVAF). A combination of dVAF and pVAF was used to define MCR. Results: The reduction of ctDNA (dVAF |
Databáze: | OpenAIRE |
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