Role of oxidative stress in the efficacy and toxicity of herbal supplements
| Autor: | Ali Moballegh, Romi Ghose, Gabriel Tao, Fatima Dagher |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant business.industry Mechanism (biology) medicine.medical_treatment Therapeutic effect 010501 environmental sciences Pharmacology Toxicology medicine.disease_cause medicine.disease complex mixtures 01 natural sciences Nephrotoxicity 03 medical and health sciences 030104 developmental biology Diabetes mellitus Toxicity Medicine business Adverse effect Oxidative stress 0105 earth and related environmental sciences |
| Zdroj: | Current Opinion in Toxicology. :36-40 |
| ISSN: | 2468-2020 |
| Popis: | The importance of oxidative stress has been increasingly recognized in diabetes and related cardiovascular complications as well as in chemical-induced toxicity, which makes it a potential therapeutic target for tackling such health issues. On the other hand, numerous herbal supplements have been reported effective to prevent diabetes and chemical-induced organ injury. Recently, emerging studies indicate that antioxidation is a possible mechanism responsible for the therapeutic effect of herbal extracts. Hereby, we reviewed the most recent studies regarding the antioxidant effect of herbal supplements. Also, we summarized the herbal extracts causing hepatotoxicity and nephrotoxicity via oxidative stress. We aim to highlight the importance of oxidative stress in the therapeutic effectiveness of herbal supplements, as well as in mediating their adverse effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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