Pancreatic Carcinogenesis: Effect of Secretin in the Hamster-Nitrosamine Model2

Autor:	David C. Carter, Allan G. Howatson
Rok vydání:	1987
Předmět:	Cancer Research medicine.medical_specialty Hamster medicine.disease_cause Secretin chemistry.chemical_compound medicine.anatomical_structure Endocrinology Oncology chemistry Cocarcinogen Nitrosamine Internal medicine Pancreatic juice medicine Carcinogenesis Pancreas Carcinogen
Zdroj:	JNCI: Journal of the National Cancer Institute. 78:101-105
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/78.1.101
Popis:	The effect of exogenous secretin on pancreatic carcinogenesis in WO strain hamsters has been examined in the nitrosamine-ductular adenocarcinoma model. Secretin, 20 clinical U/kg, stimulated a maximal secretory response of pancreatic juice and bicarbonate when given iv. The same dose given sc for 6 weeks had no significant effect on pancreatic wet weight and DNA or RNA contents. However, when given to animals receiving N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4] (5 mg/kg), it reduced the latency and increased the induction rate of tumor development when compared with the carcinogen given alone to animals (secretin + BOP, 15 of 17 animals with tumors; BOP alone, 4 of 13 with tumors at 15 wk; P less than .002). These effects are consistent with secretin acting as a cocarcinogen in this model of pancreatic carcinogenesis.
Databáze:	OpenAIRE
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