ChemInform Abstract: New Fluorine-Containing Hypotensive Preparations
Autor: | B. M. Klebanov, Dmitrij V. Fedyuk, I. I. Maletina, R. Handrock, S. S. Shavaran, K. I. Petko, S. Herzig, Lev M. Yagupolskii |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 32 |
ISSN: | 1522-2667 0931-7597 |
Popis: | The synthesis and pharmacological properties of a novel type of vasorelaxant hybrid compounds are described. The investigated compounds are based on fluorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium channel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are discussed. |
Databáze: | OpenAIRE |
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