ChemInform Abstract: New Fluorine-Containing Hypotensive Preparations

Autor:	B. M. Klebanov, Dmitrij V. Fedyuk, I. I. Maletina, R. Handrock, S. S. Shavaran, K. I. Petko, S. Herzig, Lev M. Yagupolskii
Rok vydání:	2010
Předmět:	Benzimidazole Calcium channel Fluorine containing General Medicine Ring (chemistry) Combinatorial chemistry Medicinal chemistry Potassium channel chemistry.chemical_compound Losartan chemistry Nitrogen atom Pinacidil medicine medicine.drug
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
Popis:	The synthesis and pharmacological properties of a novel type of vasorelaxant hybrid compounds are described. The investigated compounds are based on fluorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium channel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::623a4fbc61eb095ba8f920f1b332b76e https://doi.org/10.1002/chin.200134297 Zobrazit plný text záznamu Plný text