The influence of experimentally induced hepatotoxicity on the pressor responses to vasoactive substances in beagle dogs*1
| Autor: | D.L. Bokelman, E.E. Vogin |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Pharmacology
medicine.medical_specialty Pentobarbital Ethionine business.industry Diastole Toxicology Beagle Norepinephrine (medication) chemistry.chemical_compound Endocrinology Epinephrine chemistry Internal medicine Renin–angiotensin system medicine Alkaline phosphatase business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 20:291-298 |
| ISSN: | 0041-008X |
| Popis: | This investigation was undertaken to study the influence of chemically induced hepatotoxicity in beagles upon the pressor responses to angiotensin, norepinephrine, and epinephrine. Dogs were administered either CCl 4 (2.0 ml/kg for 2 days) or ethionine (25 or 50 mg/kg for 18–20 days). Hepatotoxicity was confirmed by elevation of SGOT, alkaline phosphatase, and/or plasma half-life of indocyanine green. The animals were then anesthetized with pentobarbital sodium, and the pressor responses to graded doses of angiotensin, norepinephrine, and epinephrine were determined and compared to responses obtained in normal anesthetized animals. Ethionine treatment resulted in a reduction of systolic pressor responses to angiotensin of about 35%. Diastolic pressor responses were decreased approximately 25%. The systolic pressor responses to norepinephrine were reduced by approximately 25%, while the diastolic pressor responses were not significantly altered. Ethionine treatment only slightly depressed the pressor responses to epinephrine. CCl 4 treatment potentiated the pressor effects of the vasopressor agents. Histomorphologic data confirmed the clinical findings of hepatotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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