Comparison of Clinicopathological Features and Long-Term Prognosis Between Mixed Predominantly Differentiated-Type and Pure Differentiated-Type Early Gastric Cancer

Autor: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara, Michiaki Hirayama, Yumiko Oyamada, Shunichi Okushiba
Rok vydání: 2020
DOI: 10.21203/rs.3.rs-44824/v1
Popis: Background: Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC. Methods: We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC.Results: A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD group, respectively. Submucosal invasion was found in 96 (23.5%) of the PD group and in 33 (66.0%) of the MD group (pConclusions: MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.
Databáze: OpenAIRE