Synthesis and Structural Analysis of 1,4,7,10‐Tetraazacyclododecane‐1,4,7,10‐­tetraazidoethylacetic Acid (DOTAZA) Complexes

Autor:	Malte Holzapfel, Ella Kriemen, Julia Rehbein, Wolfgang Maison, Erik Ruf
Rok vydání:	2015
Předmět:	medicine.diagnostic_test Chemistry Stereochemistry Metal ions in aqueous solution Crystal structure Combinatorial chemistry Inorganic Chemistry Metal chemistry.chemical_compound Positron emission tomography visual_art visual_art.visual_art_medium medicine DOTA Chelation Azide Luminescence
Zdroj:	European Journal of Inorganic Chemistry. 2015:5368-5378
ISSN:	1099-0682 1434-1948
Popis:	Herein, we present the synthesis and structural analysis of metal complexes of enantiomerically pure 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraazidoethylacetic acid (DOTAZA). DOTAZA is a new tunable analog of DOTA, a clinically approved chelator for various pharmaceutically relevant metal ions. In this work, we investigate the complexation chemistry of DOTAZA and report the crystal structures of a number of complexes with pharmaceutically relevant metal ions such as Gd3+ [magnetic resonance imaging (MRI)], Eu3+ (luminescence spectroscopy), Y3+ [positron emission tomography (PET)], In3+ [single-photon-emission computed tomography (SPECT)], and Na+. These structures provide useful information for imaging applications and demonstrate the potential of DOTAZA to form stable complexes. Owing to its clickable azide functionalities, it may be used for the development of tailored imaging reagents that retain the positive complexation chemistry of the parent compound DOTA.
Databáze:	OpenAIRE
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