| Popis: |
Mouse brain microarray dataset (GDS2702) on embryonic days 14.5 (E14.5), 16.5 (E16.5 and 18.5 (E18.5) was investigated for gene expression patterns of GABA receptors. Gabbr1, Gabra2, Gabrb3 and Gabrg2 were the only four GABA receptor genes expressed at stage E14.5 and E16.5. However, at stage E18.5, four additional genes (Gabra1, Gabra3, Gabrg1 and Gabrg3) were expressed. Gabbr1 had the highest intensity in all the three embryonic days. Gabra6, Gabrb2, Gabrd, Gabrr1 and Gabrr2 were not expressed in all the 3 samples analyzed. It is proposed that Gabra6 receptor is a potential biomarker for neuronal toxicity that can arise from maternal exposures to low doses of mercury through diet, water and air pollutions. |
