Type I Cryoglobulinemia With a Fatal Outcome
| Autor: | B. Echeverría, Francisco A. Kerdel, Magalys Vitiello, Adriana Abuchar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology Histology Fatal outcome business.industry medicine.medical_treatment Lymphoproliferative disorders Dermatology medicine.disease Cryoglobulinemia Pathology and Forensic Medicine Sepsis hemic and lymphatic diseases Monoclonal Medicine Rituximab Plasmapheresis business Vasculitis medicine.drug |
| Zdroj: | Actas Dermo-Sifiliográficas (English Edition). 102:212-215 |
| ISSN: | 1578-2190 |
| DOI: | 10.1016/s1578-2190(11)70787-9 |
| Popis: | Type I cryoglobulinemia, a condition associated with lymphoproliferative disorders, is caused by monoclonal immunoglobulins that precipitate at low temperatures. It mostly involves the skin and pathology study shows no signs of vasculitis. Management is usually based on immunosuppressive drugs associated with plasmapheresis for severe disease. The use of rituximab has recently been described for resistant cases. We present an unusual case of long-standing type I cryoglobulinemia associated with a monoclonal gammopathy of unknown significance. The patient developed extremely severe skin lesions with histological signs of vasculitis. The patient died due to the onset of noncutaneous manifestations of the cryoglobulinemia and complications of the immunosuppressive treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect