The biogenic amine transporter activity of vinylogous amphetamine analogs
| Autor: | Richard B. Rothman, Michael H. Baumann, John S. Partilla, Ann M. Decker, Bruce E. Blough |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stereochemistry Pharmaceutical Science Pharmacology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine Biogenic amine Drug Discovery medicine Abuse liability Receptor Amphetamine chemistry.chemical_classification Organic Chemistry Transporter 030104 developmental biology chemistry Molecular Medicine Serotonin Lead compound 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | MedChemComm. 7:1657-1663 |
| ISSN: | 2040-2511 2040-2503 |
| Popis: | A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S-6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|