Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds

Autor:	Erika Tassano, Andrea Galatini, Renata Riva, Giancarlo Dondo, Andrea Basso, Luca Banfi, Angela Alama
Rok vydání:	2015
Předmět:	chemistry.chemical_compound chemistry Polyphenol Organic Chemistry Triazole food and beverages Organic chemistry Hydroxytyrosol Ether Physical and Theoretical Chemistry Cytotoxicity
Zdroj:	European Journal of Organic Chemistry. 2015:6710-6726
ISSN:	1434-193X
DOI:	10.1002/ejoc.201500931
Popis:	Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::61d6babf88c3b8ba3a22e27bb8b71fd4 https://doi.org/10.1002/ejoc.201500931 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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