Comparison of total body irradiation versus non-total body irradiation containing regimens for de novo acute myeloid leukemia in children
| Autor: | Stella M. Davies, Nahal R. Lalefar, Tracy O'Brien, Mary Eapen, Lena E. Winestone, Kwang Woo Ahn, Shahinaz M. Gadalla, Stephanie Bo-Subait, Margaret L. MacMillan, Peter J. Shaw, Anders Kolb, Neel S. Bhatt, Yizeng He, Joseph Chewing, Jason Law, Timothy Prestidge, Nicholas J. Gloude, Christopher E. Dandoy, Akshay Sharma, Hisham Abdel-Azim, John E. Levine, Robert J. Hayashi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Myeloid Cyclophosphamide business.industry medicine.medical_treatment Myeloid leukemia Hematology Hematopoietic stem cell transplantation Total body irradiation medicine.disease Gastroenterology nervous system diseases 03 medical and health sciences Regimen Leukemia 0302 clinical medicine medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Internal medicine Medicine business Busulfan 030215 immunology medicine.drug |
| Zdroj: | Haematologica. 106:1839-1845 |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2020.249458 |
| Popis: | With limited data comparing hematopoietic cell transplant outcomes between myeloablative total body irradiation (TBI) containing and non-TBI regimens in children with de novo acute myeloid leukemia, the aim of this study was to compare transplant-outcomes between these regimens. Cox regression models were used to compare transplant-outcomes after TBI and non-TBI regimens in 624 children transplanted between 2008 and 2016. Thirty two percent (n=199) received TBI regimens whereas 68% (n=425) received non-TBI regimens. Five-year non-relapse mortality was higher with TBI regimens (22% vs. 11%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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